SeasonfiveofMurdochMysteriesopensinunfamiliarterritory,asDetectiveWilliamMurdoch(YannickBisson)leavesTorontototryhisluckwhiletheKlondikeGoldRushintheYukonwindsdown.Suspendedforinterferinginaninvestigation,ontherunforsurreptitiouslyfreeingamurderertomakeamends,andnursingabrokenheartafterDr.Ogdensmarriagetoanotherman.Butashetriestorebuildhislife,hefindshimselfdrawnintothecaseofMrs.ElizabethBryant(JillHalfpenny),aninnkeeperchargedwithmurder.TheplotthickenswhenwriterJackLondon(AaronAshmore)lendshisinsights,andMurdochsoonrealizesthatwhilehehadhopedtoleavehisshatteredheartandtatteredcareerbackinToronto,hisdaysasadetectivearenotbehindhim.
